Addictive Disorders and Alcoholism

Biography

Biography: Sadia Yasir

Abstract

Statement of the Problem: The emphasis on Major depressive disorder has left a gap in the research, concerning the relationship between magnitude of depression severity and neurocognitive functions. The current study addresses this issue and looks at the frequency of neurocognitive deficits in depressed elderly patients. Orientation:  It is a Cross sectional descriptive study done at Institute of psychiatry availing inpatient and outpatient facility at Benazir Bhutto hospital, Rawalpindi Pakistan. Duration of Study was six months from29th September 2014 to 29th March 2015. 292 patients aged ≥60 years were screened for depression using Geriatric Depression Scale (GDS).  Neurocognitive impairment was assessed using Mini Mental State Examination (MMSE). Severity of depression was assessed by Beck Depressive inventory (BDI). Data was analyzed with statistical Program for Social Sciences (SPSS version 18). Results showed that severity of depression is associated with the neurocognitive deficits in elderly. Findings:  In a sample of (n=292) 32.19% had mild depression, out of these 48.9% had mild cognitive impairment, 20.1% had moderate and 2.1% had severe impairment. 36.9% had moderate depression out of which 34.2% had mild cognitive impairment, 41.6% had moderate and 7% had severe cognitive impairment. 16.4%had severe depression out of which 14.5%had mild neurocognitive impairment, 52%had moderate and 37.5%had severe neurocognitive impairment. Conclusions and significance: Higher BDI score was associated with a lower baseline MMSE. Depression causes significant neurocognitive impairment in elderly. This has to be differentiated from mild cognitive impairment (MCI) seen in Dementia. Caution must be taken while prescribing the class of anti-depressants as tricyclic antidepressants can further cause neurocognitive impairment.